Ireland are hoping to clinch the Triple Crown and move one step closer to the Grand Slam and a third successive title with victory over Wales, who have lost their past 14 Tests.
“Playing Wales in Cardiff is one of the great tests and we know the challenge that awaits us,” said Ireland interim head coach Simon Easterby.
“With a new coaching set-up in place, Wales will be re-energised and determined to impress in front of a vocal home support.
“There will also be a huge Irish travelling support which, when added to the closed roof and the great respect and rivalry between the two nations, will add to an electric atmosphere.”
Being named the 111th men’s player to captain Ireland in a Test match caps a remarkable comeback for Sheehan.
The 26-year-old suffered an anterior cruciate ligament injury in Ireland’s series against South Africa last summer, but returned in time to captain Leinster against the Stormers in January before making an impact off the bench in the wins over England and Scotland.
“We have made a few changes to the squad this week, some of which were enforced, and we’re confident that the 23 we have selected are primed and ready to go,” added Easterby.
“Dan Sheehan’s selection as captain is recognition of his high standing within the squad, both on and off the pitch. I have no doubt that he will relish the opportunity to lead Ireland for the first time.
“Equally, I would also like to congratulate Jack Boyle on his inclusion in the match day squad for the first time. Jack has impressed for his province Leinster and in the national training camps over the last number of months and he is a young forward with a bright future.”