Cameron spoke in the build-up about the burden of the undefeated record no longer weighing heavily on her, and she seemed to enjoy the opening rounds.
In her first fight under the tutelage of trainer Grant Smith, Cameron landed flush left hooks and bullied the backtracking Mekhaled.
The Parisian, 33, took in gasps of air as she walked back to her corner after the second and third.
But Mekhaled – who had only lost at the highest level in a 14-fight career with points defeats by Delfine Persoon and Alycia Baumgardner – did not back down.
She landed some heavy hits of her own in a terrific all-action fourth round which sparked the attention of the third-full arena.
Cameron became England’s first four-belt undisputed champion in 2022, and the gulf in class became apparent as the contest progressed.
She was beating her opponent to the punch, working the body and easing out of range of any attack.
The crowd’s interest was momentarily distracted by a brawl in the stands in the ninth round, before the boxers closed the show by continuing to let their hands go until the final seconds of the 10th.
Cameron said she is planning to return to the ring soon, adding: “It’s my first camp with Grant [Smith] – I just want to keep the momentum. I don’t want to be waiting around.”