Despite recent defeats, Warrington said there is no extra pressure on him when he steps into the ring against Cacace.
“It seems to be when my back is against the wall that I pull my best performances out,” said Warrington.
“His performance against Cordina was absolutely phenomenal. He has my full respect and we will throw the kitchen sink at each other.”
Queensberry promoter Frank Warren said he believes Cacace is a “world-class” fighter” and the bout will be “one of the great fights on the card”.
“Josh is a good fighter but I think he will be in with somebody who is coming into his own,” said Warren.
“He has had a few disappointments over the years but if you are patient and keep at it like he has done, you can show what you are capable of.
“It is a fantastic fight. The winner will have the mandatory challenge against Eduardo Nunez, so that will be a big fight, but this is one of the great fights on the card. This will be an unbelievable fight.”
Matchroom promoter Eddie Hearn added said he was delighted that Warrington had a shot at becoming a three-time, two-weight world champion at Wembley.
“Josh really deserves this. People talk about coming off the back of defeats, but just look at what he has done,” he said.
“He is a fantastic fighter and super-featherweight will really suit him. I think this could be one of the fights of the night on a tremendous card.”