The first regular-season game to be held in London was in 2007 and next season there could be as many as eight international games.
Berlin and Madrid are confirmed hosts, while other games could be held in Dublin, Mexico City and Brazil.
“This season will see us surpass 40 regular season games in the capital, a testament to the role the UK has played in growing the game globally,” said Henry Hodgson, general manager of NFL UK & Ireland.
“The London games are a continued catalyst for year-round fan engagement and we are focused on serving our 15 million fans, reaching new communities and driving growth in flag football participation, which now sees over 100,000 young people play the game.”
Each team’s opponent, along with the dates and kick-off times, will be announced when the full schedule for the NFL’s 2025 season is revealed this spring.