Sinner would become the first Italian player in history to reach an Australian Open singles’ final if he can achieve his best ever Grand Slam result at Melbourne Park this fortnight.
Italy’s rising star led his nation to the Davis Cup title in November, Sinner made a solid start to his campaign and took the first two sets with a single break of serve.
He found himself behind in the third as world number 59 Van de Zandschulp survived four break points before taking his first for a 2-0 lead.
But Sinner responded emphatically, winning six of the following seven games to close out a comfortable victory on the opening day and set up a second-round meeting with either Argentine Pedro Cachin or Dutch qualifier Jesper De Jong.
“My first match of the season and it means a lot to start off with a win,” said Sinner, who was cheered on by the ‘Carota Boys’ – his fans who attend his matches dressed as carrots.
“Physically I feel good in good shape, the first round is never easy so I can be happy with today.”
On the backing he receives from his loyal supporters, he added: “It feels good. I was not expecting them to come here, but it’s nice to see them in the stands.
“Obviously we have made some great memories together, with all the support they give me. They are getting more famous than I am slowly.
“Maybe this support gives me in the key moments this extra belief maybe. Who knows? Let’s see how it goes here. But I’m happy that they are here.”